6S4J
Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB27, desB30 human insulin
Summary for 6S4J
Entry DOI | 10.2210/pdb6s4j/pdb |
Descriptor | Insulin, IMIDAZOLE, KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl], ... (5 entities in total) |
Functional Keywords | insulin, oral, zinc free, hormone |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 6359.33 |
Authors | Johansson, E. (deposition date: 2019-06-28, release date: 2020-07-15, Last modification date: 2024-01-24) |
Primary citation | Hubalek, F.,Refsgaard, H.H.F.,Gram-Nielsen, S.,Madsen, P.,Nishimura, E.,Munzel, M.,Brand, C.L.,Stidsen, C.E.,Claussen, C.H.,Wulff, E.M.,Pridal, L.,Ribel, U.,Kildegaard, J.,Porsgaard, T.,Johansson, E.,Steensgaard, D.B.,Hovgaard, L.,Glendorf, T.,Hansen, B.F.,Jensen, M.K.,Nielsen, P.K.,Ludvigsen, S.,Rugh, S.,Garibay, P.W.,Moore, M.C.,Cherrington, A.D.,Kjeldsen, T. Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11:3746-3746, 2020 Cited by PubMed: 32719315DOI: 10.1038/s41467-020-17487-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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