6S4J
Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB27, desB30 human insulin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin | polymer | 21 | 2349.6 | 1 | UniProt (P01308) | Homo sapiens (Human) | |
| 2 | B (B) | Insulin | polymer | 28 | 3222.7 | 1 | UniProt (P01308) Pfam (PF00049) | Homo sapiens (Human) | |
| 3 | C (B) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 4 | D (B) | KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] | non-polymer | 717.9 | 1 | Chemie (KUT) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A: 1 - 21 (UniProt: P01308)
B: 1 - 28 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| Glu 14 | Tyr 103 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| His 25 | Phe 49 | engineered mutation |
| - | Thr 51 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 5572.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 787.0 | |
| All* | Total formula weight | 6359.3 |
