6S26
Crystal structure of human wild type STING in complex with 2'-3'-cyclic-GMP-7-deaza-AMP
Summary for 6S26
Entry DOI | 10.2210/pdb6s26/pdb |
Descriptor | Stimulator of interferon protein, 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-(4-azanylpyrrolo[2,3-d]pyrimidin-7-yl)-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one (3 entities in total) |
Functional Keywords | activator, membrane protein, immune system, receptor, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 47051.55 |
Authors | Boura, E.,Smola, M.,Brynda, J. (deposition date: 2019-06-20, release date: 2019-11-27, Last modification date: 2024-01-24) |
Primary citation | Novotna, B.,Vanekova, L.,Zavrel, M.,Budesinsky, M.,Dejmek, M.,Smola, M.,Gutten, O.,Tehrani, Z.A.,Pimkova Polidarova, M.,Brazdova, A.,Liboska, R.,Stepanek, I.,Vavrina, Z.,Jandusik, T.,Nencka, R.,Rulisek, L.,Boura, E.,Brynda, J.,Pav, O.,Birkus, G. Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations. J.Med.Chem., 62:10676-10690, 2019 Cited by PubMed: 31715099DOI: 10.1021/acs.jmedchem.9b01062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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