6RLZ

Crystal Structure of 14-3-3zeta in complex with a macrocyclic 8-mer peptide derived from ExoS

Summary for 6RLZ

Entry DOI	10.2210/pdb6rlz/pdb
Descriptor	14-3-3 protein zeta/delta, EtMe (3 entities in total)
Functional Keywords	protein-protein-interaction macrocycle peptide, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	54459.75
Authors	Wallraven, K.,Grossmann, T.N.,Hennig, S. (deposition date: 2019-05-03, release date: 2020-03-18, Last modification date: 2020-03-25)
Primary citation	Wallraven, K.,Holmelin, F.L.,Glas, A.,Hennig, S.,Frolov, A.I.,Grossmann, T.N. Adapting free energy perturbation simulations for large macrocyclic ligands: how to dissect contributions from direct binding and free ligand flexibility. Chem Sci, 11:2269-2276, 2020 Cited by PubMed: 32180932 DOI: 10.1039/c9sc04705k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.7 Å)

Structure validation