6RLY
Human MMP12 (catalytic domain) in complex with AP316
Summary for 6RLY
Entry DOI | 10.2210/pdb6rly/pdb |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | mmp12, inhibitors, catalytic domain, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 18290.18 |
Authors | Calderone, V.,Fragai, M.,Luchinat, C. (deposition date: 2019-05-03, release date: 2020-03-11, Last modification date: 2024-01-24) |
Primary citation | Tsoukalidou, S.,Kakou, M.,Mavridis, I.,Koumantou, D.,Calderone, V.,Fragai, M.,Stratikos, E.,Papakyriakou, A.,Vourloumis, D. Exploration of zinc-binding groups for the design of inhibitors for the oxytocinase subfamily of M1 aminopeptidases. Bioorg.Med.Chem., 27:115177-115177, 2019 Cited by PubMed: 31711716DOI: 10.1016/j.bmc.2019.115177 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report