6RFE
Human protein kinase CK2 alpha in complex with 2-cyano-2-propenamide compound 4
Summary for 6RFE
Entry DOI | 10.2210/pdb6rfe/pdb |
Related | 6RB1 6RCB 6RCM |
Descriptor | Casein kinase II subunit alpha, 1,2-ETHANEDIOL, (~{E})-~{N}-(5-bromanyl-1,3,4-thiadiazol-2-yl)-2-cyano-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enamide, ... (5 entities in total) |
Functional Keywords | kinase domain, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 40947.35 |
Authors | Dalle Vedove, A.,Zanforlin, E.,Ribaudo, G.,Zagotto, G.,Battistutta, R.,Lolli, G. (deposition date: 2019-04-13, release date: 2020-04-08, Last modification date: 2024-01-24) |
Primary citation | Dalle Vedove, A.,Zonta, F.,Zanforlin, E.,Demitri, N.,Ribaudo, G.,Cazzanelli, G.,Ongaro, A.,Sarno, S.,Zagotto, G.,Battistutta, R.,Ruzzene, M.,Lolli, G. A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur.J.Med.Chem., 195:112267-112267, 2020 Cited by PubMed: 32283296DOI: 10.1016/j.ejmech.2020.112267 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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