6R3S
CRYSTAL STRUCTURE OF CDK8-CycC IN COMPLEX WITH COMPOUND 1
Summary for 6R3S
Entry DOI | 10.2210/pdb6r3s/pdb |
Descriptor | Cyclin-dependent kinase 8, Cyclin-C, 6-[5-chloranyl-4-[(1~{S})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide, ... (6 entities in total) |
Functional Keywords | kinase, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 81348.94 |
Authors | Boettcher, J. (deposition date: 2019-03-21, release date: 2020-04-08, Last modification date: 2024-05-15) |
Primary citation | Hofmann, M.H.,Mani, R.,Engelhardt, H.,Impagnatiello, M.A.,Carotta, S.,Kerenyi, M.,Lorenzo-Herrero, S.,Bottcher, J.,Scharn, D.,Arnhof, H.,Zoephel, A.,Schnitzer, R.,Gerstberger, T.,Sanderson, M.P.,Rajgolikar, G.,Goswami, S.,Vasu, S.,Ettmayer, P.,Gonzalez, S.,Pearson, M.,McConnell, D.B.,Kraut, N.,Muthusamy, N.,Moll, J. Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19:1018-1030, 2020 Cited by PubMed: 32024684DOI: 10.1158/1535-7163.MCT-19-0789 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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