6Q9N
Crystal structure of PBP2a from MRSA in complex with piperacillin and quinazolinone
Summary for 6Q9N
Entry DOI | 10.2210/pdb6q9n/pdb |
Descriptor | Penicillin binding protein 2 prime, 3-[2-[(~{E})-2-(4-ethynylphenyl)ethenyl]-4-oxidanylidene-quinazolin-3-yl]benzoic acid, Piperacillin (Open Form), ... (7 entities in total) |
Functional Keywords | penicillin binding protein, hydrolase |
Biological source | Staphylococcus aureus (strain Mu50 / ATCC 700699) |
Total number of polymer chains | 2 |
Total formula weight | 148327.98 |
Authors | Martinez-Caballero, S.,Batuecas, M.T.,Hermoso, J.A. (deposition date: 2018-12-18, release date: 2019-11-27, Last modification date: 2024-01-24) |
Primary citation | Janardhanan, J.,Bouley, R.,Martinez-Caballero, S.,Peng, Z.,Batuecas-Mordillo, M.,Meisel, J.E.,Ding, D.,Schroeder, V.A.,Wolter, W.R.,Mahasenan, K.V.,Hermoso, J.A.,Mobashery, S.,Chang, M. The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus. Antimicrob.Agents Chemother., 63:-, 2019 Cited by PubMed: 30858202DOI: 10.1128/AAC.02637-18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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