6PL4

TRK-A IN COMPLEX WITH LIGAND 1

Summary for 6PL4

Entry DOI	10.2210/pdb6pl4/pdb
Descriptor	High affinity nerve growth factor receptor, N-{[5-(methoxymethyl)-2-(trifluoromethoxy)phenyl]methyl}-N'-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)urea (3 entities in total)
Functional Keywords	trk-a kinase domain, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35914.18
Authors	Subramanian, G.,Brown, D.G. (deposition date: 2019-06-30, release date: 2020-07-01, Last modification date: 2021-11-03)
Primary citation	Subramanian, G.,Duclos, B.,Johnson, P.D.,Williams, T.,Ross, J.T.,Bowen, S.J.,Zhu, Y.,White, J.A.,Hedke, C.,Huczek, D.,Collard, W.,Javens, C.,Vairagoundar, R.,Respondek, T.,Zachary, T.,Maddux, T.,Cox, M.R.,Kamerling, S.,Gonzales, A.J. In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain Acs Med.Chem.Lett., 2021 Cited by DOI: 10.1021/acsmedchemlett.1c00483 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.06 Å)

Structure validation