6PL1
TRK-A IN COMPLEX WITH LIGAND 1B
Summary for 6PL1
Entry DOI | 10.2210/pdb6pl1/pdb |
Descriptor | High affinity nerve growth factor receptor, N-(5-{[(7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-N'-[3-(trifluoromethyl)phenyl]urea (3 entities in total) |
Functional Keywords | trk-a kinase domain high affinity nerve growth factor receptor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35921.22 |
Authors | Subramanian, G. (deposition date: 2019-06-30, release date: 2019-10-09, Last modification date: 2019-10-30) |
Primary citation | Subramanian, G.,Zhu, Y.,Bowen, S.J.,Roush, N.,White, J.A.,Huczek, D.,Zachary, T.,Javens, C.,Williams, T.,Janssen, A.,Gonzales, A. Lead identification and characterization of hTrkA type 2 inhibitors. Bioorg.Med.Chem.Lett., 29:126680-126680, 2019 Cited by PubMed: 31610943DOI: 10.1016/j.bmcl.2019.126680 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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