6P38
Crystal Structure Analysis of TAF1 Bromodomain
Summary for 6P38
Entry DOI | 10.2210/pdb6p38/pdb |
Descriptor | Transcription initiation factor TFIID subunit 1, 4-{[(3R)-4-cyclopentyl-1,3-dimethyl-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl]amino}-N-(1-methylpiperidin-4-yl)-3-[(propan-2-yl)oxy]benzamide (2 entities in total) |
Functional Keywords | kinase, bromodomain, inhibitor, transcription, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16417.51 |
Authors | Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2019-05-23, release date: 2020-05-27, Last modification date: 2023-10-11) |
Primary citation | Remillard, D.,Buckley, D.L.,Seo, H.S.,Ferguson, F.M.,Dhe-Paganon, S.,Bradner, J.E.,Gray, N.S. Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold. Acs Med.Chem.Lett., 10:1443-1449, 2019 Cited by PubMed: 31620231DOI: 10.1021/acsmedchemlett.9b00243 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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