6OHG

Structure of Plasmodium falciparum vaccine candidate Pfs230D1M in complex with the Fab of a transmission blocking antibody

Summary for 6OHG

Entry DOI	10.2210/pdb6ohg/pdb
Descriptor	Gametocyte surface protein P230, 4F12 Light Chain, 4F12 Heavy chain, ... (9 entities in total)
Functional Keywords	malaria, transmission blocking, sexual stage, 6 cysteine-rich pfs230, immune system
Biological source	Plasmodium falciparum More
Total number of polymer chains	3
Total formula weight	71554.18
Authors	Garboczi, D.N.,Singh, K.,Gittis, A.G. (deposition date: 2019-04-05, release date: 2020-06-17, Last modification date: 2021-03-31)
Primary citation	Singh, K.,Burkhardt, M.,Nakuchima, S.,Herrera, R.,Muratova, O.,Gittis, A.G.,Kelnhofer, E.,Reiter, K.,Smelkinson, M.,Veltri, D.,Swihart, B.J.,Shimp Jr., R.,Nguyen, V.,Zhang, B.,MacDonald, N.J.,Duffy, P.E.,Garboczi, D.N.,Narum, D.L. Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins. Commun Biol, 3:395-395, 2020 Cited by PubMed: 32709983 DOI: 10.1038/s42003-020-01123-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.385 Å)

Structure validation