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6NJS

Stat3 Core in complex with compound SD36

Summary for 6NJS
Entry DOI10.2210/pdb6njs/pdb
DescriptorSignal transducer and activator of transcription 3, [(2-{[(5S,8S,10aR)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro)methyl]phosphonic acid (non-preferred name) (3 entities in total)
Functional Keywordsstat3, activator, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight65253.75
Authors
Meagher, J.L.,Stuckey, J.A. (deposition date: 2019-01-04, release date: 2019-12-04, Last modification date: 2023-10-11)
Primary citationBai, L.,Zhou, H.,Xu, R.,Zhao, Y.,Chinnaswamy, K.,McEachern, D.,Chen, J.,Yang, C.Y.,Liu, Z.,Wang, M.,Liu, L.,Jiang, H.,Wen, B.,Kumar, P.,Meagher, J.L.,Sun, D.,Stuckey, J.A.,Wang, S.
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
Cancer Cell, 36:498-511.e17, 2019
Cited by
PubMed: 31715132
DOI: 10.1016/j.ccell.2019.10.002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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