6NJS

Stat3 Core in complex with compound SD36

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0007165	biological_process	signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue KQV A 701

Chain	Residue
A	ASP173
A	THR620
A	SER636
A	VAL637
A	GLU638
A	PRO639
A	TYR640
A	GLN644
A	TYR657
A	LYS658
A	ILE659
A	TYR176
A	HOH804
A	HOH832
A	HOH837
A	HOH839
A	HOH907
A	LYS290
A	SER292
A	TYR293
A	ARG609
A	SER611
A	GLU612
A	SER613

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	90
Details	Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Motif: {"description":"Essential for nuclear import"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"28065600","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by TYK2","evidences":[{"source":"PubMed","id":"29162862","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"15653507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28065600","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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