6NB1

Crystal structure of Escherichia coli ClpP protease complexed with small molecule activator, ACP1-06

Summary for 6NB1

Entry DOI	10.2210/pdb6nb1/pdb
Descriptor	ATP-dependent Clp protease proteolytic subunit, N-{2-[(2-chlorophenyl)sulfanyl]ethyl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	serine protease, antibiotic, hydrolase
Biological source	Escherichia coli (strain K12)
Total number of polymer chains	14
Total formula weight	332803.37
Authors	Mabanglo, M.F.,Houry, W.A.,Eger, B.T.,Bryson, S.,Pai, E.F. (deposition date: 2018-12-06, release date: 2019-11-13, Last modification date: 2023-10-11)
Primary citation	Mabanglo, M.F.,Leung, E.,Vahidi, S.,Seraphim, T.V.,Eger, B.T.,Bryson, S.,Bhandari, V.,Zhou, J.L.,Mao, Y.Q.,Rizzolo, K.,Barghash, M.M.,Goodreid, J.D.,Phanse, S.,Babu, M.,Barbosa, L.R.S.,Ramos, C.H.I.,Batey, R.A.,Kay, L.E.,Pai, E.F.,Houry, W.A. ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores. Commun Biol, 2:410-410, 2019 Cited by PubMed: 31925204 DOI: 10.1038/s42003-019-0656-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation