6MU1

Structure of full-length IP3R1 channel bound with Adenophostin A

Summary for 6MU1

Entry DOI	10.2210/pdb6mu1/pdb
EMDB information	9243 9244
Descriptor	Inositol 1,4,5-trisphosphate receptor type 1, Adenophostin A (2 entities in total)
Functional Keywords	inositol 1, 4, 5-trisphosphate receptor, calcium release channel, neuronal type 1, adenophostin a, membrane protein, ip3r-channel activator
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	4
Total formula weight	1252445.29
Authors	Serysheva, I.I.,Fan, G.,Baker, M.R.,Wang, Z.,Seryshev, A.,Ludtke, S.J.,Baker, M.L. (deposition date: 2018-10-22, release date: 2018-12-05, Last modification date: 2019-11-27)
Primary citation	Fan, G.,Baker, M.R.,Wang, Z.,Seryshev, A.B.,Ludtke, S.J.,Baker, M.L.,Serysheva, I.I. Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating. Cell Res., 28:1158-1170, 2018 Cited by PubMed: 30470765 DOI: 10.1038/s41422-018-0108-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.1 Å)

Structure validation