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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6MU1

Structure of full-length IP3R1 channel bound with Adenophostin A

Functional Information from GO Data
ChainGOidnamespacecontents
A0000902biological_processcell morphogenesis
A0001666biological_processresponse to hypoxia
A0005216molecular_functionmonoatomic ion channel activity
A0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005635cellular_componentnuclear envelope
A0005637cellular_componentnuclear inner membrane
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005955cellular_componentcalcineurin complex
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006915biological_processapoptotic process
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
A0007338biological_processsingle fertilization
A0009791biological_processpost-embryonic development
A0010976biological_processpositive regulation of neuron projection development
A0014069cellular_componentpostsynaptic density
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016358biological_processdendrite development
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0019855molecular_functioncalcium channel inhibitor activity
A0019903molecular_functionprotein phosphatase binding
A0019904molecular_functionprotein domain specific binding
A0030425cellular_componentdendrite
A0030658cellular_componenttransport vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0030868cellular_componentsmooth endoplasmic reticulum membrane
A0031088cellular_componentplatelet dense granule membrane
A0031094cellular_componentplatelet dense tubular network
A0031410cellular_componentcytoplasmic vesicle
A0032024biological_processpositive regulation of insulin secretion
A0032469biological_processendoplasmic reticulum calcium ion homeostasis
A0032991cellular_componentprotein-containing complex
A0034220biological_processmonoatomic ion transmembrane transport
A0035091molecular_functionphosphatidylinositol binding
A0036444biological_processcalcium import into the mitochondrion
A0042045biological_processepithelial fluid transport
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050849biological_processnegative regulation of calcium-mediated signaling
A0050882biological_processvoluntary musculoskeletal movement
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0051480biological_processregulation of cytosolic calcium ion concentration
A0051928biological_processpositive regulation of calcium ion transport
A0055085biological_processtransmembrane transport
A0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A0070588biological_processcalcium ion transmembrane transport
A0070679molecular_functioninositol 1,4,5 trisphosphate binding
A0071320biological_processcellular response to cAMP
A0071456biological_processcellular response to hypoxia
A0097060cellular_componentsynaptic membrane
A0097421biological_processliver regeneration
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098695molecular_functioninositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098982cellular_componentGABA-ergic synapse
A0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
A1903514biological_processrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
A1990806biological_processligand-gated ion channel signaling pathway
A2000347biological_processpositive regulation of hepatocyte proliferation
B0000902biological_processcell morphogenesis
B0001666biological_processresponse to hypoxia
B0005216molecular_functionmonoatomic ion channel activity
B0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005635cellular_componentnuclear envelope
B0005637cellular_componentnuclear inner membrane
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0005955cellular_componentcalcineurin complex
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006915biological_processapoptotic process
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
B0007338biological_processsingle fertilization
B0009791biological_processpost-embryonic development
B0010976biological_processpositive regulation of neuron projection development
B0014069cellular_componentpostsynaptic density
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016358biological_processdendrite development
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0019855molecular_functioncalcium channel inhibitor activity
B0019903molecular_functionprotein phosphatase binding
B0019904molecular_functionprotein domain specific binding
B0030425cellular_componentdendrite
B0030658cellular_componenttransport vesicle membrane
B0030667cellular_componentsecretory granule membrane
B0030868cellular_componentsmooth endoplasmic reticulum membrane
B0031088cellular_componentplatelet dense granule membrane
B0031094cellular_componentplatelet dense tubular network
B0031410cellular_componentcytoplasmic vesicle
B0032024biological_processpositive regulation of insulin secretion
B0032469biological_processendoplasmic reticulum calcium ion homeostasis
B0032991cellular_componentprotein-containing complex
B0034220biological_processmonoatomic ion transmembrane transport
B0035091molecular_functionphosphatidylinositol binding
B0036444biological_processcalcium import into the mitochondrion
B0042045biological_processepithelial fluid transport
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0044325molecular_functiontransmembrane transporter binding
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050849biological_processnegative regulation of calcium-mediated signaling
B0050882biological_processvoluntary musculoskeletal movement
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051289biological_processprotein homotetramerization
B0051480biological_processregulation of cytosolic calcium ion concentration
B0051928biological_processpositive regulation of calcium ion transport
B0055085biological_processtransmembrane transport
B0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
B0070588biological_processcalcium ion transmembrane transport
B0070679molecular_functioninositol 1,4,5 trisphosphate binding
B0071320biological_processcellular response to cAMP
B0071456biological_processcellular response to hypoxia
B0097060cellular_componentsynaptic membrane
B0097421biological_processliver regeneration
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098695molecular_functioninositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098982cellular_componentGABA-ergic synapse
B0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
B1903514biological_processrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
B1990806biological_processligand-gated ion channel signaling pathway
B2000347biological_processpositive regulation of hepatocyte proliferation
C0000902biological_processcell morphogenesis
C0001666biological_processresponse to hypoxia
C0005216molecular_functionmonoatomic ion channel activity
C0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005635cellular_componentnuclear envelope
C0005637cellular_componentnuclear inner membrane
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005955cellular_componentcalcineurin complex
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006915biological_processapoptotic process
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
C0007338biological_processsingle fertilization
C0009791biological_processpost-embryonic development
C0010976biological_processpositive regulation of neuron projection development
C0014069cellular_componentpostsynaptic density
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016358biological_processdendrite development
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0019855molecular_functioncalcium channel inhibitor activity
C0019903molecular_functionprotein phosphatase binding
C0019904molecular_functionprotein domain specific binding
C0030425cellular_componentdendrite
C0030658cellular_componenttransport vesicle membrane
C0030667cellular_componentsecretory granule membrane
C0030868cellular_componentsmooth endoplasmic reticulum membrane
C0031088cellular_componentplatelet dense granule membrane
C0031094cellular_componentplatelet dense tubular network
C0031410cellular_componentcytoplasmic vesicle
C0032024biological_processpositive regulation of insulin secretion
C0032469biological_processendoplasmic reticulum calcium ion homeostasis
C0032991cellular_componentprotein-containing complex
C0034220biological_processmonoatomic ion transmembrane transport
C0035091molecular_functionphosphatidylinositol binding
C0036444biological_processcalcium import into the mitochondrion
C0042045biological_processepithelial fluid transport
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0044325molecular_functiontransmembrane transporter binding
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050849biological_processnegative regulation of calcium-mediated signaling
C0050882biological_processvoluntary musculoskeletal movement
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0051480biological_processregulation of cytosolic calcium ion concentration
C0051928biological_processpositive regulation of calcium ion transport
C0055085biological_processtransmembrane transport
C0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
C0070588biological_processcalcium ion transmembrane transport
C0070679molecular_functioninositol 1,4,5 trisphosphate binding
C0071320biological_processcellular response to cAMP
C0071456biological_processcellular response to hypoxia
C0097060cellular_componentsynaptic membrane
C0097421biological_processliver regeneration
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098695molecular_functioninositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098982cellular_componentGABA-ergic synapse
C0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
C1903514biological_processrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
C1990806biological_processligand-gated ion channel signaling pathway
C2000347biological_processpositive regulation of hepatocyte proliferation
D0000902biological_processcell morphogenesis
D0001666biological_processresponse to hypoxia
D0005216molecular_functionmonoatomic ion channel activity
D0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005635cellular_componentnuclear envelope
D0005637cellular_componentnuclear inner membrane
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0005955cellular_componentcalcineurin complex
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006915biological_processapoptotic process
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
D0007338biological_processsingle fertilization
D0009791biological_processpost-embryonic development
D0010976biological_processpositive regulation of neuron projection development
D0014069cellular_componentpostsynaptic density
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016358biological_processdendrite development
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0019855molecular_functioncalcium channel inhibitor activity
D0019903molecular_functionprotein phosphatase binding
D0019904molecular_functionprotein domain specific binding
D0030425cellular_componentdendrite
D0030658cellular_componenttransport vesicle membrane
D0030667cellular_componentsecretory granule membrane
D0030868cellular_componentsmooth endoplasmic reticulum membrane
D0031088cellular_componentplatelet dense granule membrane
D0031094cellular_componentplatelet dense tubular network
D0031410cellular_componentcytoplasmic vesicle
D0032024biological_processpositive regulation of insulin secretion
D0032469biological_processendoplasmic reticulum calcium ion homeostasis
D0032991cellular_componentprotein-containing complex
D0034220biological_processmonoatomic ion transmembrane transport
D0035091molecular_functionphosphatidylinositol binding
D0036444biological_processcalcium import into the mitochondrion
D0042045biological_processepithelial fluid transport
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043066biological_processnegative regulation of apoptotic process
D0044325molecular_functiontransmembrane transporter binding
D0044877molecular_functionprotein-containing complex binding
D0045202cellular_componentsynapse
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0050849biological_processnegative regulation of calcium-mediated signaling
D0050882biological_processvoluntary musculoskeletal movement
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051289biological_processprotein homotetramerization
D0051480biological_processregulation of cytosolic calcium ion concentration
D0051928biological_processpositive regulation of calcium ion transport
D0055085biological_processtransmembrane transport
D0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
D0070588biological_processcalcium ion transmembrane transport
D0070679molecular_functioninositol 1,4,5 trisphosphate binding
D0071320biological_processcellular response to cAMP
D0071456biological_processcellular response to hypoxia
D0097060cellular_componentsynaptic membrane
D0097421biological_processliver regeneration
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098695molecular_functioninositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098982cellular_componentGABA-ergic synapse
D0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
D1903514biological_processrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
D1990806biological_processligand-gated ion channel signaling pathway
D2000347biological_processpositive regulation of hepatocyte proliferation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues400
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10506212","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues88
DetailsTopological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10506212","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues84
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10506212","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues216
DetailsDomain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues200
DetailsDomain: {"description":"MIR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues224
DetailsDomain: {"description":"MIR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues224
DetailsDomain: {"description":"MIR 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21892169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22286060","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36376291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T8S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8EAR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21892169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22286060","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T8S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22286060","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UJ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P11881","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q14573","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36376291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EAR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36376291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8EAR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues8
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P11881","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues16
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"18955483","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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