6MSA
Novel, potent, selective and brain penetrant phosphodiesterase 10A inhibitors
Summary for 6MSA
Entry DOI | 10.2210/pdb6msa/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 77149.93 |
Authors | Jakob, C.G. (deposition date: 2018-10-16, release date: 2019-01-09, Last modification date: 2024-03-13) |
Primary citation | Geneste, H.,Drescher, K.,Jakob, C.,Laplanche, L.,Ochse, M.,Torrent, M. Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors. Bioorg. Med. Chem. Lett., 29:406-412, 2019 Cited by PubMed: 30587449DOI: 10.1016/j.bmcl.2018.12.029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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