6MOZ

Structure of acid-beta-glucosidase in complex with an aromatic pyrrolidine iminosugar inhibitor

Summary for 6MOZ

Entry DOI	10.2210/pdb6moz/pdb
Descriptor	Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... (7 entities in total)
Functional Keywords	tim-barrel, glycosidase, cerezyme, hydrolysis, hydrolase, inhibitor complex, pharmacological chaperone
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	113449.53
Authors	Patterson-Orazem, A.C.,Lieberman, R.L. (deposition date: 2018-10-05, release date: 2019-06-19, Last modification date: 2023-10-11)
Primary citation	Martinez-Bailen, M.,Carmona, A.T.,Patterson-Orazem, A.C.,Lieberman, R.L.,Ide, D.,Kubo, M.,Kato, A.,Robina, I.,Moreno-Vargas, A.J. Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of beta-glucocerebrosidase inhibition. Bioorg.Chem., 86:652-664, 2019 Cited by PubMed: 30825709 DOI: 10.1016/j.bioorg.2019.02.025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation