6MOZ
Structure of acid-beta-glucosidase in complex with an aromatic pyrrolidine iminosugar inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glucosylceramidase | polymer | 497 | 55640.2 | 2 | UniProt (P04062) Pfam (PF02055) Pfam (PF17189) | Homo sapiens (Human) | Acid beta-glucosidase,Alglucerase,Beta-glucocerebrosidase,Beta-GC,D-glucosyl-N-acylsphingosine glucohydrolase,Imiglucerase |
| 2 | C, W (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 3 | AA, BA, CA, D, DA... (B, A) | SODIUM ION | non-polymer | 23.0 | 32 | Chemie (NA) | |||
| 4 | S (A) | (2R,3S,4R)-2-{[4-(3,5-dichlorophenyl)-1H-1,2,3-triazol-1-yl]methyl}pyrrolidine-3,4-diol | non-polymer | 329.2 | 1 | Chemie (JXA) | |||
| 5 | PA, QA, RA, T, U... (B, A) | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) | |||
| 6 | OA (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | SA, TA (A, B) | water | water | 18.0 | 112 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 497 (UniProt: P04062)
| PDB | External Database | Details |
|---|---|---|
| His 495 | Arg 514 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111280.3 | |
| Non-Polymers* | Number of molecules | 42 |
| Total formula weight | 2169.2 | |
| All* | Total formula weight | 113449.5 |
