6LZZ
Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a
Summary for 6LZZ
Entry DOI | 10.2210/pdb6lzz/pdb |
Descriptor | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase-inhibitor complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 77100.41 |
Authors | Huang, Y.Y.,Wu, Y.,Luo, H.B. (deposition date: 2020-02-19, release date: 2021-02-24, Last modification date: 2023-11-29) |
Primary citation | Tian, Y.J.,Zhou, Q.,Zhang, P.,Jiang, M.Y.,Zhang, B.,Wu, X.N.,Zhang, C.,Li, Z.,Wu, Y.,Chen, Z.,Luo, H.B. Identification of phosphodiesterase-9 as a novel target for pulmonary arterial hypertension by using highly selective and orally bioavailable inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.40003752238 Å) |
Structure validation
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