6LZZ
Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | polymer | 322 | 38088.1 | 2 | UniProt (O76083) Pfam (PF00233) In PDB | Homo sapiens (Human) | |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | A, B | 1-cyclopentyl-6-[[(2R)-1-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one | non-polymer | 372.4 | 2 | Chemie (EZU) | |||
| 5 | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76176.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 924.3 | |
| All* | Total formula weight | 77100.4 |
