6LNQ

The co-crystal structure of SARS-CoV 3C Like Protease with aldehyde inhibitor M7

Summary for 6LNQ

Entry DOI	10.2210/pdb6lnq/pdb
Descriptor	Severe Acute Respiratory Syndrome Coronavirus 3c Like Protease, N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxidanylidene-1-[[(2S)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-1-oxidanylidene-butan-2-yl]-1H-indole-2-carboxamide (3 entities in total)
Functional Keywords	coronavirus 3c, protease, viral protein-inhibitor complex, viral protein/inhibitor
Biological source	Severe acute respiratory syndrome-related coronavirus (SARSr-CoV)
Total number of polymer chains	1
Total formula weight	34388.25
Authors	Wang, H.,Shang, L.Q. (deposition date: 2020-01-01, release date: 2020-05-27, Last modification date: 2023-11-22)
Primary citation	Wang, H.,He, S.,Deng, W.,Zhang, Y.,Li, G.,Sun, J.,Zhao, W.,Guo, Y.,Yin, Z.,Li, D.,Shang, L. Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease. Acs Catalysis, 10:5871-5890, 2020 Cited by PubMed: 32391184 DOI: 10.1021/acscatal.0c00110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.244 Å)

Structure validation