6LB6

Crystal structure of dimeric RXR-LBD complexed with partial agonist NEt-4IB and TIF2 co-activator

Summary for 6LB6

Entry DOI	10.2210/pdb6lb6/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 6-[ethyl-[4-(2-methylpropoxy)-3-propan-2-yl-phenyl]amino]pyridine-3-carboxylic acid, ... (4 entities in total)
Functional Keywords	nuclear receptor, retinoid x receptor alpha, active form, co-factors, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	29060.62
Authors	Imai, D.,Numoto, N.,Nakano, S.,Kakuta, H.,Ito, N. (deposition date: 2019-11-13, release date: 2020-11-18, Last modification date: 2024-10-02)
Primary citation	Imai, D.,Numoto, N.,Tokiwa, H.,Kakuta, H.,Ito, N. Structural basis for the full and partial agonist activities of retinoid X receptor alpha ligands with an iso-butoxy and an isopropyl group Biochem.Biophys.Res.Commun., 734:150617-, 2024 Cited by DOI: 10.1016/j.bbrc.2024.150617 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation