6LB6
Crystal structure of dimeric RXR-LBD complexed with partial agonist NEt-4IB and TIF2 co-activator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 243 | 27124.3 | 1 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B (B) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 1 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | C (A) | 6-[ethyl-[4-(2-methylpropoxy)-3-propan-2-yl-phenyl]amino]pyridine-3-carboxylic acid | non-polymer | 356.5 | 1 | Chemie (E8O) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A: 224 - 462 (UniProt: P19793)
| PDB | External Database | Details |
|---|---|---|
| Gly 220 | - | expression tag |
| Ser 221 | - | expression tag |
| Ser 222 | - | expression tag |
| His 223 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28704.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 356.5 | |
| All* | Total formula weight | 29060.6 |
