6KZV
Crystal structure of E.coli DNA gyrase B in complex with 2-oxo-1,2-dihydroquinoline derivative
Summary for 6KZV
Entry DOI | 10.2210/pdb6kzv/pdb |
Descriptor | DNA gyrase subunit B, ~{N}-[2-[[cyclohexyl(methyl)amino]methyl]phenyl]-2-oxidanylidene-1~{H}-quinoline-3-carboxamide (3 entities in total) |
Functional Keywords | inhibitor, complex, topoisomerase, escherichia coli, isomerase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 24580.67 |
Authors | Mima, M.,Ushiyama, F. (deposition date: 2019-09-25, release date: 2020-05-06, Last modification date: 2023-11-22) |
Primary citation | Ushiyama, F.,Amada, H.,Takeuchi, T.,Tanaka-Yamamoto, N.,Kanazawa, H.,Nakano, K.,Mima, M.,Masuko, A.,Takata, I.,Hitaka, K.,Iwamoto, K.,Sugiyama, H.,Ohtake, N. Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation. Acs Omega, 5:10145-10159, 2020 Cited by PubMed: 32391502DOI: 10.1021/acsomega.0c00865 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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