6K7O
Complex structure of LILRB4 and h128-3 antibody
Summary for 6K7O
Entry DOI | 10.2210/pdb6k7o/pdb |
Descriptor | Leukocyte immunoglobulin-like receptor subfamily B member 4, h128-3 Fab heavy chain, h128-3 Fab light chain (3 entities in total) |
Functional Keywords | lilrb4, antibody, immune therapy., immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 235461.63 |
Authors | |
Primary citation | Gui, X.,Deng, M.,Song, H.,Chen, Y.,Xie, J.,Li, Z.,He, L.,Huang, F.,Xu, Y.,Anami, Y.,Yu, H.,Yu, C.,Li, L.,Yuan, Z.,Xu, X.,Wang, Q.,Chai, Y.,Huang, T.,Shi, Y.,Tsuchikama, K.,Liao, X.C.,Xia, N.,Gao, G.F.,Zhang, N.,Zhang, C.C.,An, Z. Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development. Cancer Immunol Res, 7:1244-1257, 2019 Cited by PubMed: 31213474DOI: 10.1158/2326-6066.CIR-19-0036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.004 Å) |
Structure validation
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