6JN4
Serine Beta-Lactamase KPC-2 in Complex with Dual MBL/SBL Inhibitor WL-001
Summary for 6JN4
Entry DOI | 10.2210/pdb6jn4/pdb |
Descriptor | Serine Beta-Lactamase KPC-2, [(R)-(4-fluorophenyl)-[[(2S)-2-methyl-3-sulfanyl-propanoyl]amino]methyl]boronic acid, ACETATE ION, ... (6 entities in total) |
Functional Keywords | beta-lactamase, serine-beta-lactamase kpc-2, kpc-2, carbapenemase, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 4 |
Total formula weight | 114788.20 |
Authors | |
Primary citation | Wang, Y.L.,Liu, S.,Yu, Z.J.,Lei, Y.,Huang, M.Y.,Yan, Y.H.,Ma, Q.,Zheng, Y.,Deng, H.,Sun, Y.,Wu, C.,Yu, Y.,Chen, Q.,Wang, Z.,Wu, Y.,Li, G.B. Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases. J.Med.Chem., 62:7160-7184, 2019 Cited by PubMed: 31269398DOI: 10.1021/acs.jmedchem.9b00735 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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