6JLI
Crystal structure of CTLD7 domain of human PLA2R
Summary for 6JLI
| Entry DOI | 10.2210/pdb6jli/pdb |
| Descriptor | Secretory phospholipase A2 receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
| Functional Keywords | imn, epitope, pla2r, ctld7, immune system |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 15540.28 |
| Authors | |
| Primary citation | Yu, B.,Hu, Z.,Kong, D.,Cheng, C.,He, Y. Crystal structure of the CTLD7 domain of human M-type phospholipase A2 receptor. J.Struct.Biol., 207:295-300, 2019 Cited by PubMed Abstract: M-type phospholipase A2 receptor (PLA2R) is a member of the mannose receptor family. Recent evidence shows that PLA2R is a major autoantigen causing idiopathic membranous nephropathy (IMN), which is an autoimmune disease and one of the most common causes for nephrotic syndrome in adults. The epitope mapping data suggest that the major epitopes of PLA2R locate at the CysR, CTLD1 and CTLD7 domains. However, due to the lack of the high-resolution structural information, it is unclear how the autoantibodies interact with PLA2R. Here we determine the crystal structure of the CTLD7 domain of PLA2R at 1.8 Å, showing that it adopts a typical CTLD fold, and the structural alignments also provide hints for the potential antibody binding regions. In addition, the high-resolution structural information of CTLD7 could be applied to identify the epitopes for autoantibodies, which would facilitate the therapeutic strategies against IMN. PubMed: 31271865DOI: 10.1016/j.jsb.2019.06.007 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.778 Å) |
Structure validation
Download full validation report
