6J71
HuA21-scFv in complex with the extracellular domain(ECD) of HER2
Summary for 6J71
Entry DOI | 10.2210/pdb6j71/pdb |
Descriptor | Receptor tyrosine-protein kinase erbB-2, anti-HER2 humanized antibody HuA21, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | tyrosine-protein kinase, antibody, transcription regulation, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 95889.77 |
Authors | |
Primary citation | Wang, Z.,Cheng, L.,Guo, G.,Cheng, B.,Hu, S.,Zhang, H.,Zhu, Z.,Niu, L. Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells. Acta Crystallogr D Struct Biol, 75:554-563, 2019 Cited by PubMed: 31205018DOI: 10.1107/S2059798319006995 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.918 Å) |
Structure validation
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