6J6M
Co-crystal structure of BTK kinase domain with Zanubrutinib
Summary for 6J6M
Entry DOI | 10.2210/pdb6j6m/pdb |
Descriptor | Tyrosine-protein kinase BTK, (7S)-2-(4-phenoxyphenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, IMIDAZOLE, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 31894.64 |
Authors | |
Primary citation | Guo, Y.,Liu, Y.,Hu, N.,Yu, D.,Zhou, C.,Shi, G.,Zhang, B.,Wei, M.,Liu, J.,Luo, L.,Tang, Z.,Song, H.,Guo, Y.,Liu, X.,Su, D.,Zhang, S.,Song, X.,Zhou, X.,Hong, Y.,Chen, S.,Cheng, Z.,Young, S.,Wei, Q.,Wang, H.,Wang, Q.,Lv, L.,Wang, F.,Xu, H.,Sun, H.,Xing, H.,Li, N.,Zhang, W.,Wang, Z.,Liu, G.,Sun, Z.,Zhou, D.,Li, W.,Liu, L.,Wang, L.,Wang, Z. Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. J.Med.Chem., 62:7923-7940, 2019 Cited by PubMed: 31381333DOI: 10.1021/acs.jmedchem.9b00687 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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