6J1L
Crystal Structure Analysis of the ROR gamma(C455E)
Summary for 6J1L
Entry DOI | 10.2210/pdb6j1l/pdb |
Descriptor | Nuclear receptor ROR-gamma, 2-[4-(ethylsulfonyl)phenyl]-N-[2'-fluoro-4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)[1,1'-biphenyl]-4-yl]acetamide (3 entities in total) |
Functional Keywords | ror gamma, lbd, inhibitor, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 95077.23 |
Authors | |
Primary citation | Zhang, Y.,Wu, X.,Xue, X.,Li, C.,Wang, J.,Wang, R.,Zhang, C.,Wang, C.,Shi, Y.,Zou, L.,Li, Q.,Huang, Z.,Hao, X.,Loomes, K.,Wu, D.,Chen, H.W.,Xu, J.,Xu, Y. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. J.Med.Chem., 62:4716-4730, 2019 Cited by PubMed: 30964293DOI: 10.1021/acs.jmedchem.9b00327 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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