6J1L

Crystal Structure Analysis of the ROR gamma(C455E)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Nuclear receptor ROR-gamma	polymer	267	31128.9	3	UniProt (P51449) Pfam (PF00104)	Homo sapiens (Human)	Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma
2	D, E, F (A, B, C)	2-[4-(ethylsulfonyl)phenyl]-N-[2'-fluoro-4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)[1,1'-biphenyl]-4-yl]acetamide	non-polymer		563.5	3	Chemie (B6L)
3	G, H, I (A, B, C)	water	water		18.0	71	Chemie (HOH)

Sequence modifications

A, B, C: 262 - 507 (UniProt: P51449)

PDB	External Database	Details
Glu 241	-	expression tag
Gly 242	-	expression tag
Asp 243	-	expression tag
Ile 244	-	expression tag
His 245	-	expression tag
Met 246	-	expression tag
Lys 247	-	expression tag
Lys 248	-	expression tag
Gly 249	-	expression tag
Tyr 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
His 254	-	expression tag
His 255	-	expression tag
Leu 256	-	expression tag
Val 257	-	expression tag
Pro 258	-	expression tag
Arg 259	-	expression tag
Gly 260	-	expression tag
Ser 261	-	expression tag
Glu 455	Cys 455	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	93386.8
Non-Polymers*	Number of molecules	3
	Total formula weight	1690.5
All*	Total formula weight	95077.2

*Water molecules are not included.