6IZZ
The RNA-dependent RNA polymerase domain of dengue 3 NS5, bound with RK-0404678
Summary for 6IZZ
Entry DOI | 10.2210/pdb6izz/pdb |
Descriptor | Genome polyprotein, ZINC ION, 2-oxo-2H-1,3-benzoxathiol-5-yl acetate, ... (4 entities in total) |
Functional Keywords | dengue, ns5, rna-dependent rna polymerase, viral protein |
Biological source | Dengue virus 3 |
Total number of polymer chains | 1 |
Total formula weight | 75140.02 |
Authors | Shimizu, H.,Sekine, S. (deposition date: 2018-12-20, release date: 2019-12-25, Last modification date: 2023-11-22) |
Primary citation | Shimizu, H.,Saito, A.,Mikuni, J.,Nakayama, E.E.,Koyama, H.,Honma, T.,Shirouzu, M.,Sekine, S.I.,Shioda, T. Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13:e0007894-e0007894, 2019 Cited by PubMed: 31738758DOI: 10.1371/journal.pntd.0007894 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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