6IZP

Solution structure of the complex of naphthyridine carbamate dimer and an RNA with UGGAA-UGGAA pentad

Summary for 6IZP

• Entry DOI: 10.2210/pdb6izp/pdb
• Descriptor: RNA (29-MER), 3-[3-[(7-methyl-1,8-naphthyridin-2-yl)carbamoyloxy]propylamino]propyl ~{N}-(7-methyl-1,8-naphthyridin-2-yl)carbamate (2 entities in total)
• Functional Keywords: sca31, uggaa repeat, small molecule, drug, rna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 10333.66

Authors

Nagano, K.,Shibata, T.,Nakatani, K.,Kawai, G. (deposition date: 2018-12-20, release date: 2019-12-25, Last modification date: 2024-05-15)

• Primary citation: Shibata, T.,Nagano, K.,Ueyama, M.,Ninomiya, K.,Hirose, T.,Nagai, Y.,Ishikawa, K.,Kawai, G.,Nakatani, K.; Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model; Nat Commun, 12:-, 2021; DOI: 10.1038/s41467-020-20487-4

Experimental method

SOLUTION NMR