6ILQ
Crystal structure of PPARgamma with compound BR101549
Summary for 6ILQ
Entry DOI | 10.2210/pdb6ilq/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, ethyl [2-butyl-6-oxo-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl}-4-(propan-2-yl)-1,6-dihydropyrimidin-5-yl]acetate, ... (4 entities in total) |
Functional Keywords | peroxisome proliferator-activated receptor-g(ppar-g), transcription factor, ligand-binding domain, steroid receptor coactivator-1, nuclear protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 34430.91 |
Authors | |
Primary citation | Choung, W.,Jung, H.J.,Yang, D.,Nam, E.H.,Choi, H.,Lee, B.R.,Park, M.,Jang, S.M.,Lim, J.S.,Kim, W.S.,Kim, K.H.,Chin, J.,Jung, K.,Lee, G.,Hong, E.,Jang, T.H.,Myung, J.,Kim, S.H. Identification of BR101549 as a lead candidate of non-TZD PPAR gamma agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR. Bioorg.Med.Chem.Lett., 29:631-637, 2019 Cited by PubMed: 30594432DOI: 10.1016/j.bmcl.2018.12.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.408 Å) |
Structure validation
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