6IHH
Crystal structure of RasADH F12 from Ralstonia.sp in complex with NADPH and A6O
Summary for 6IHH
Entry DOI | 10.2210/pdb6ihh/pdb |
Descriptor | Alclohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R,3S)-2-ethyl-2-[(2E)-2-(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)ethyl]-3-oxidanyl-cyclopentan-1-one, ... (4 entities in total) |
Functional Keywords | oxidoreductase, kred, biocatalyst, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Ralstonia sp. |
Total number of polymer chains | 2 |
Total formula weight | 55063.50 |
Authors | Zhang, H.L.,Chen, X.,Liu, W.D.,Wu, Q.Q.,Zhu, D.M. (deposition date: 2018-09-30, release date: 2019-10-02, Last modification date: 2023-11-22) |
Primary citation | Chen, X.,Zhang, H.,Ma, M.S.,Liu, W.,Li, J.,Feng, J.,Liu, X.,Osuna, S.,Guo, R.T.,Wu, Q.,Zhu, D.,Ma, Y. Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase. Nat Catal, 2:931-941, 2019 Cited by DOI: 10.1038/s41929-019-0347-yPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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