6I99
Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24
Summary for 6I99
Entry DOI | 10.2210/pdb6i99/pdb |
Descriptor | Cytoplasmic tyrosine-protein kinase BMX, ~{N}-[2-methyl-5-[8-[4-(methylsulfonylamino)phenyl]-2-oxidanylidene-benzo[h][1,6]naphthyridin-1-yl]phenyl]-3-oxidanyl-propanamide (3 entities in total) |
Functional Keywords | cytoplasmic tyrosine-kinase bmx, homo sapiens, cytosolic protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 66214.04 |
Authors | Sousa, B.B.,Matias, P.M.,Marques, M.C.,Seixas, J.D.,Bernardes, G.J.L. (deposition date: 2018-11-22, release date: 2020-05-27, Last modification date: 2024-01-24) |
Primary citation | Seixas, J.D.,Sousa, B.B.,Marques, M.C.,Guerreiro, A.,Traquete, R.,Rodrigues, T.,Albuquerque, I.S.,Sousa, M.F.Q.,Lemos, A.R.,Sousa, P.M.F.,Bandeiras, T.M.,Wu, D.,Doyle, S.K.,Robinson, C.V.,Koehler, A.N.,Corzana, F.,Matias, P.M.,Bernardes, G.J.L. Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors Chem.Biol., 2020 Cited by DOI: 10.1039/D0CB00033GPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.001 Å) |
Structure validation
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