Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue H88 A 701 |
| Chain | Residue |
| A | VAL431 |
| A | CYS496 |
| A | ASN499 |
| A | ARG540 |
| A | LEU543 |
| A | HOH812 |
| B | LEU420 |
| B | LYS435 |
| A | ALA443 |
| A | LYS445 |
| A | THR489 |
| A | GLU490 |
| A | TYR491 |
| A | ILE492 |
| A | SER493 |
| A | GLY495 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide H88 B 701 and CYS B 496 |
| Chain | Residue |
| A | LEU420 |
| A | LYS435 |
| B | LYS445 |
| B | THR489 |
| B | GLU490 |
| B | ILE492 |
| B | SER493 |
| B | GLY495 |
| B | LEU497 |
| B | LEU498 |
| B | ASN499 |
| B | TYR500 |
| B | ARG540 |
| B | CYS542 |
| B | LEU543 |
| B | HOH806 |
| B | HOH808 |
| B | HOH819 |
| B | HOH827 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 23 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGQFGVVKlGkwkgqyd...........VAVK |
| Chain | Residue | Details |
| A | LEU423-LYS445 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV |
| Chain | Residue | Details |
| A | PHE532-VAL544 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Motif: {"description":"CAV1-binding"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by SRC and autocatalysis","evidences":[{"source":"PubMed","id":"10688651","evidenceCode":"ECO:0000269"}]} |
