6I74
Galectin-3C in complex with substituted polyfluoroaryl monothiogalactoside derivative 1
Summary for 6I74
Entry DOI | 10.2210/pdb6i74/pdb |
Descriptor | Galectin-3, (2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyl-4-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol (3 entities in total) |
Functional Keywords | lectin, carbohydrate-binding protein, galactose-specific lectin 3, galactoside-binding protein, galbp, ige-6 binding protein, l-31, laminin-binding protein, lectin l-29, mac-2, sugar binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16204.49 |
Authors | Kumar, R.,Peterson, K.,Nilsson, U.J.,Logan, D.T. (deposition date: 2018-11-15, release date: 2019-01-23, Last modification date: 2024-01-24) |
Primary citation | Kumar, R.,Peterson, K.,Misini Ignjatovic, M.,Leffler, H.,Ryde, U.,Nilsson, U.J.,Logan, D.T. Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects. Org. Biomol. Chem., 17:1081-1089, 2019 Cited by PubMed: 30632578DOI: 10.1039/c8ob02888e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.959 Å) |
Structure validation
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