6HUP
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam (Valium), GABA and megabody Mb38.
Summary for 6HUP
Entry DOI | 10.2210/pdb6hup/pdb |
EMDB information | 0283 |
Descriptor | Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, GAMMA-AMINO-BUTANOIC ACID, 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, ... (11 entities in total) |
Functional Keywords | gabaar, membrane protein, cys-loop, plgic |
Biological source | Bos taurus (Bovine) More |
Total number of polymer chains | 6 |
Total formula weight | 337547.37 |
Authors | Masiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Jasenko, Z.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. (deposition date: 2018-10-09, release date: 2019-01-02, Last modification date: 2023-11-15) |
Primary citation | Masiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Zivanov, J.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565:454-459, 2019 Cited by PubMed: 30602790DOI: 10.1038/s41586-018-0832-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.58 Å) |
Structure validation
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