6HSX
Thrombin in Complex with a D-Phe-Pro-diaminopyridine derivative
Summary for 6HSX
Entry DOI | 10.2210/pdb6hsx/pdb |
Descriptor | Prothrombin, Hirudin variant-2, DIMETHYL SULFOXIDE, ... (10 entities in total) |
Functional Keywords | coagulation, blood clotting, convertion of fibrinogen to fibrin, blood clotting inhibitor, thrombin inhibitor, preorganization, glycosylation, blood, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 36453.35 |
Authors | |
Primary citation | Ngo, K.,Collins-Kautz, C.,Gerstenecker, S.,Wagner, B.,Heine, A.,Klebe, G. Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins? J.Med.Chem., 63:3274-3289, 2020 Cited by PubMed: 32011145DOI: 10.1021/acs.jmedchem.9b02061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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