6HKM
Crystal structure of Compound 1 with ERK5
Summary for 6HKM
Entry DOI | 10.2210/pdb6hkm/pdb |
Descriptor | Mitogen-activated protein kinase 7, [4-(6,7-dimethoxyquinazolin-4-yl)piperidin-1-yl]-[4-(trifluoromethyloxy)phenyl]methanone (3 entities in total) |
Functional Keywords | erk5 kinase, immune system, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 40187.18 |
Authors | Nguyen, D.,Lemos, C.,Wortmann, L.,Eis, K.,Holton, S.J.,Boemer, U.,Lechner, C.,Prechtl, S.,Suelze, D.,Siegel, F.,Prinz, F.,Lesche, R.,Nicke, B.,Mumberg, D.,Bauser, M.,Haegebarth, A. (deposition date: 2018-09-07, release date: 2019-02-27, Last modification date: 2024-05-15) |
Primary citation | Nguyen, D.,Lemos, C.,Wortmann, L.,Eis, K.,Holton, S.J.,Boemer, U.,Moosmayer, D.,Eberspaecher, U.,Weiske, J.,Lechner, C.,Prechtl, S.,Suelzle, D.,Siegel, F.,Prinz, F.,Lesche, R.,Nicke, B.,Nowak-Reppel, K.,Himmel, H.,Mumberg, D.,von Nussbaum, F.,Nising, C.F.,Bauser, M.,Haegebarth, A. Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J. Med. Chem., 62:928-940, 2019 Cited by PubMed: 30563338DOI: 10.1021/acs.jmedchem.8b01606 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.47 Å) |
Structure validation
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