6H8S

CRYSTAL STRUCTURE OF THE MOUSE PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND BI-0314

Summary for 6H8S

Entry DOI	10.2210/pdb6h8s/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 5, 1-[3-piperidin-4-yl-5-(trifluoromethyl)phenyl]guanidine (3 entities in total)
Functional Keywords	protein phosphatase, ptn5, step, allosteric modulator, hydrolase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	35166.87
Authors	Fiegen, D.,Schnapp, G. (deposition date: 2018-08-03, release date: 2018-09-26, Last modification date: 2024-01-17)
Primary citation	Tautermann, C.S.,Binder, F.,Buttner, F.H.,Eickmeier, C.,Fiegen, D.,Gross, U.,Grundl, M.A.,Heilker, R.,Hobson, S.,Hoerer, S.,Luippold, A.,Mack, V.,Montel, F.,Peters, S.,Bhattacharya, S.,Vaidehi, N.,Schnapp, G.,Thamm, S.,Zeeb, M. Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. J. Med. Chem., 62:306-316, 2019 Cited by PubMed: 30207464 DOI: 10.1021/acs.jmedchem.8b00857 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.771 Å)

Structure validation