6H8S
CRYSTAL STRUCTURE OF THE MOUSE PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND BI-0314
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 5 | polymer | 301 | 34880.6 | 1 | UniProt (P54830) Pfam (PF00102) | Mus musculus (Mouse) | Neural-specific protein-tyrosine phosphatase,Striatum-enriched protein-tyrosine phosphatase,STEP |
| 2 | B (A) | 1-[3-piperidin-4-yl-5-(trifluoromethyl)phenyl]guanidine | non-polymer | 286.3 | 1 | Chemie (FSZ) | |||
| 3 | C (A) | water | water | 18.0 | 277 | Chemie (HOH) |
Sequence modifications
A: 244 - 539 (UniProt: P54830)
| PDB | External Database | Details |
|---|---|---|
| Gly 239 | - | expression tag |
| His 240 | - | expression tag |
| Met 241 | - | expression tag |
| Ala 242 | - | expression tag |
| Ser 243 | - | expression tag |
| Thr 426 | Ser 426 | conflict |
| His 537 | Leu 537 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34880.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 286.3 | |
| All* | Total formula weight | 35166.9 |
