6GY0
mPI3Kd IN COMPLEX WITH AZ3
Summary for 6GY0
Entry DOI | 10.2210/pdb6gy0/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ~{N}-[4-methyl-5-(1-oxidanylidene-7-sulfamoyl-isoindol-5-yl)-1,3-thiazol-2-yl]ethanamide (3 entities in total) |
Functional Keywords | inhibitor, pi3k, transferase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 108002.88 |
Authors | Petersen, J. (deposition date: 2018-06-27, release date: 2019-02-06, Last modification date: 2024-05-01) |
Primary citation | Gangadhara, G.,Dahl, G.,Bohnacker, T.,Rae, R.,Gunnarsson, J.,Blaho, S.,Oster, L.,Lindmark, H.,Karabelas, K.,Pemberton, N.,Tyrchan, C.,Mogemark, M.,Wymann, M.P.,Williams, R.L.,Perry, M.W.D.,Papavoine, T.,Petersen, J. A class of highly selective inhibitors bind to an active state of PI3K gamma. Nat.Chem.Biol., 15:348-357, 2019 Cited by PubMed: 30718815DOI: 10.1038/s41589-018-0215-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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