6GPI

Tc-DNA/DNA duplex

Summary for 6GPI

• Entry DOI: 10.2210/pdb6gpi/pdb
• NMR Information: BMRB: 34280
• Descriptor: tc-DNA (5'-D(*(TCJ)P*(TTK)P*(TCJ)P*(TCS)P*(TCS)P*(TCJ)P*(TTK)P*(TTK)P*(TCY)P*(TCJ))-3'), DNA (5'-D(*GP*TP*AP*AP*GP*CP*CP*GP*AP*G)-3') (2 entities in total)
• Functional Keywords: tricyclo-dna, modified nucleic acids, modified oligonucleotide, tc-dna, dna-rna hybrid
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 6446.62

Authors

Istrate, A.,Johannsen, S.,Istrate, A.,Sigel, R.K.O.,Leumann, C. (deposition date: 2018-06-05, release date: 2018-06-13, Last modification date: 2024-05-15)

• Primary citation: Istrate, A.,Johannsen, S.,Istrate, A.,Sigel, R.K.O.,Leumann, C.J.; NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance.; Nucleic Acids Res., 47:4872-4882, 2019; PubMed: 30916334; DOI: 10.1093/nar/gkz197

Experimental method

SOLUTION NMR