6GJ4

Tubulin-6j complex

Summary for 6GJ4

• Entry DOI: 10.2210/pdb6gj4/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265303.10

Authors

Brindisi, M.,Ulivieri, C.,Alfano, G.,Gemma, S.,Balaguer, F.d.A.,Khan, T.,Grillo, A.,Chemi, G.,Menchon, G.,Prota, A.E.,Olieric, N.,Agell, D.L.,Barasoain, I.,Diaz, J.F.,Nebbioso, A.,Conte, M.R.,Lopresti, L.,Magnano, S.,Amet, R.,Kinsella, P.,Zisterer, D.M.,Ibrahim, O.,O'Sullivan, J.,Morbidelli, L.,Spaccapelo, R.,Baldari, C.,Butini, S.,Novellino, E.,Campiani, G.,Altucci, L.,Steinmetz, M.O.,Brogi, S. (deposition date: 2018-05-16, release date: 2018-12-05, Last modification date: 2024-01-17)

• Primary citation: Brindisi, M.,Ulivieri, C.,Alfano, G.,Gemma, S.,de Asis Balaguer, F.,Khan, T.,Grillo, A.,Chemi, G.,Menchon, G.,Prota, A.E.,Olieric, N.,Lucena-Agell, D.,Barasoain, I.,Diaz, J.F.,Nebbioso, A.,Conte, M.,Lopresti, L.,Magnano, S.,Amet, R.,Kinsella, P.,Zisterer, D.M.,Ibrahim, O.,O'Sullivan, J.,Morbidelli, L.,Spaccapelo, R.,Baldari, C.,Butini, S.,Novellino, E.,Campiani, G.,Altucci, L.,Steinmetz, M.O.,Brogi, S.; Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.; Eur J Med Chem, 162:290-320, 2018; PubMed: 30448418; DOI: 10.1016/j.ejmech.2018.11.004

Experimental method

X-RAY DIFFRACTION (2.4 Å)