6GEY
Trypanosoma brucei PTR1 in complex with inhibitor 4g (F125)
Summary for 6GEY
Entry DOI | 10.2210/pdb6gey/pdb |
Related | 6GCK 6GCL 6GCP 6GCQ 6GD0 6GD4 6GDO 6GDP 6GEX |
Descriptor | Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-azanyl-~{N}-[(3,4-dichlorophenyl)methyl]-1,3-benzothiazole-6-carboxamide, ... (6 entities in total) |
Functional Keywords | trypanosoma brucei, pteridine reductase, ptr1, tbptr1, benzothiazole, oxidoreductase |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 4 |
Total formula weight | 127355.18 |
Authors | Landi, G.,Pozzi, C.,Mangani, S. (deposition date: 2018-04-27, release date: 2019-04-03, Last modification date: 2024-01-17) |
Primary citation | Linciano, P.,Pozzi, C.,Iacono, L.D.,di Pisa, F.,Landi, G.,Bonucci, A.,Gul, S.,Kuzikov, M.,Ellinger, B.,Witt, G.,Santarem, N.,Baptista, C.,Franco, C.,Moraes, C.B.,Muller, W.,Wittig, U.,Luciani, R.,Sesenna, A.,Quotadamo, A.,Ferrari, S.,Pohner, I.,Cordeiro-da-Silva, A.,Mangani, S.,Costantino, L.,Costi, M.P. Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. J.Med.Chem., 62:3989-4012, 2019 Cited by PubMed: 30908048DOI: 10.1021/acs.jmedchem.8b02021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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