6GEY
Trypanosoma brucei PTR1 in complex with inhibitor 4g (F125)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0047040 | molecular_function | pteridine reductase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0047040 | molecular_function | pteridine reductase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0047040 | molecular_function | pteridine reductase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0047040 | molecular_function | pteridine reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | binding site for residue NAP A 301 |
| Chain | Residue |
| A | ARG14 |
| A | THR64 |
| A | ASN93 |
| A | ALA94 |
| A | SER95 |
| A | THR126 |
| A | LEU159 |
| A | CYS160 |
| A | ASP161 |
| A | TYR174 |
| A | LYS178 |
| A | ILE15 |
| A | PRO204 |
| A | GLY205 |
| A | SER207 |
| A | LEU208 |
| A | EWT302 |
| A | HOH414 |
| A | HOH416 |
| A | HOH420 |
| A | HOH427 |
| A | HOH431 |
| A | TYR34 |
| A | HOH468 |
| A | HOH506 |
| A | HOH531 |
| A | HOH537 |
| A | HIS35 |
| A | ASN36 |
| A | SER37 |
| A | ALA61 |
| A | ASP62 |
| A | LEU63 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue EWT A 302 |
| Chain | Residue |
| A | SER95 |
| A | PHE97 |
| A | ASP161 |
| A | CYS168 |
| A | TYR174 |
| A | LEU209 |
| A | MET213 |
| A | TRP221 |
| A | NAP301 |
| A | HOH590 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 303 |
| Chain | Residue |
| A | ASP161 |
| A | MET163 |
| A | PRO167 |
| A | CYS168 |
| A | TYR174 |
| A | ASN175 |
| site_id | AC4 |
| Number of Residues | 29 |
| Details | binding site for residue NAP B 301 |
| Chain | Residue |
| B | ARG14 |
| B | ILE15 |
| B | TYR34 |
| B | HIS35 |
| B | ASN36 |
| B | SER37 |
| B | ALA61 |
| B | ASP62 |
| B | LEU63 |
| B | THR64 |
| B | ASN93 |
| B | ALA94 |
| B | SER95 |
| B | THR126 |
| B | LEU159 |
| B | CYS160 |
| B | TYR174 |
| B | LYS178 |
| B | PRO204 |
| B | GLY205 |
| B | SER207 |
| B | LEU208 |
| B | EWT302 |
| B | HOH412 |
| B | HOH433 |
| B | HOH435 |
| B | HOH457 |
| B | HOH474 |
| B | HOH513 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EWT B 302 |
| Chain | Residue |
| B | SER95 |
| B | PHE97 |
| B | ASP161 |
| B | CYS168 |
| B | TYR174 |
| B | GLU217 |
| B | TRP221 |
| B | NAP301 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue DMS B 303 |
| Chain | Residue |
| B | ASP161 |
| B | MET163 |
| B | PRO167 |
| B | CYS168 |
| B | TYR174 |
| B | ASN175 |
| site_id | AC7 |
| Number of Residues | 32 |
| Details | binding site for residue NAP C 301 |
| Chain | Residue |
| C | ASP62 |
| C | LEU63 |
| C | THR64 |
| C | ASN93 |
| C | ALA94 |
| C | SER95 |
| C | THR126 |
| C | LEU159 |
| C | CYS160 |
| C | ASP161 |
| C | TYR174 |
| C | LYS178 |
| C | PRO204 |
| C | GLY205 |
| C | VAL206 |
| C | SER207 |
| C | LEU208 |
| C | EWT302 |
| C | HOH406 |
| C | HOH407 |
| C | HOH418 |
| C | HOH459 |
| C | HOH462 |
| C | HOH482 |
| C | HOH486 |
| C | ARG14 |
| C | ILE15 |
| C | TYR34 |
| C | HIS35 |
| C | ASN36 |
| C | SER37 |
| C | ALA61 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue EWT C 302 |
| Chain | Residue |
| C | SER95 |
| C | PHE97 |
| C | ASP161 |
| C | CYS168 |
| C | TYR174 |
| C | LEU209 |
| C | PRO210 |
| C | MET213 |
| C | TRP221 |
| C | NAP301 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue ACT C 303 |
| Chain | Residue |
| B | TYR34 |
| B | VAL58 |
| C | VAL57 |
| C | VAL58 |
| C | HOH433 |
| site_id | AD1 |
| Number of Residues | 32 |
| Details | binding site for residue NAP D 301 |
| Chain | Residue |
| D | ARG14 |
| D | ILE15 |
| D | TYR34 |
| D | HIS35 |
| D | ASN36 |
| D | SER37 |
| D | ALA61 |
| D | ASP62 |
| D | LEU63 |
| D | THR64 |
| D | ASN93 |
| D | ALA94 |
| D | SER95 |
| D | THR126 |
| D | LEU159 |
| D | CYS160 |
| D | ASP161 |
| D | TYR174 |
| D | LYS178 |
| D | PRO204 |
| D | GLY205 |
| D | SER207 |
| D | LEU208 |
| D | EWT302 |
| D | HOH409 |
| D | HOH410 |
| D | HOH411 |
| D | HOH416 |
| D | HOH422 |
| D | HOH502 |
| D | HOH511 |
| D | HOH532 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for residue EWT D 302 |
| Chain | Residue |
| D | SER95 |
| D | PHE97 |
| D | ASP161 |
| D | CYS168 |
| D | TYR174 |
| D | VAL206 |
| D | PRO210 |
| D | MET213 |
| D | TRP221 |
| D | NAP301 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue DMS D 303 |
| Chain | Residue |
| D | ASP161 |
| D | MET163 |
| D | PRO167 |
| D | CYS168 |
| D | TYR174 |
| D | ASN175 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. DamvdqpcmaFslYNMGKHALvGLTqSAA |
| Chain | Residue | Details |
| A | ASP161-ALA189 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 237 |
| Chain | Residue | Details |
| A | ARG14 | electrostatic stabiliser, hydrogen bond donor, steric role |
| A | ASP161 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | TYR174 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 237 |
| Chain | Residue | Details |
| B | ARG14 | electrostatic stabiliser, hydrogen bond donor, steric role |
| B | ASP161 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| B | TYR174 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 237 |
| Chain | Residue | Details |
| C | ARG14 | electrostatic stabiliser, hydrogen bond donor, steric role |
| C | ASP161 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| C | TYR174 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 237 |
| Chain | Residue | Details |
| D | ARG14 | electrostatic stabiliser, hydrogen bond donor, steric role |
| D | ASP161 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| D | TYR174 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
